MUTATIONAL SIGNATURES IN CANCER GENOMES 🎗️
“𝕋𝕙𝕖 𝕘𝕖𝕟𝕠𝕞𝕖 𝕠𝕗 𝕖𝕧𝕖𝕣𝕪 𝕔𝕒𝕟𝕔𝕖𝕣 𝕡𝕣𝕠𝕧𝕚𝕕𝕖𝕤 𝕒 𝕜𝕚𝕟𝕕 𝕠𝕗 ‘𝕒𝕣𝕔𝕙𝕒𝕖𝕠𝕝𝕠𝕘𝕚𝕔𝕒𝕝 𝕣𝕖𝕔𝕠𝕣𝕕,’ 𝕨𝕣𝕚𝕥𝕥𝕖𝕟 𝕚𝕟 𝕥𝕙𝕖 𝔻ℕ𝔸 𝕔𝕠𝕕𝕖 𝕚𝕥𝕤𝕖𝕝𝕗, 𝕠𝕗 𝕥𝕙𝕖 𝕖𝕩𝕡𝕠𝕤𝕦𝕣𝕖𝕤 𝕥𝕙𝕒𝕥 𝕔𝕒𝕦𝕤𝕖𝕕 𝕥𝕙𝕖 𝕞𝕦𝕥𝕒𝕥𝕚𝕠𝕟𝕤 𝕥𝕙𝕒𝕥 𝕝𝕖𝕒𝕕 𝕥𝕠 𝕥𝕙𝕖 𝕔𝕒𝕟𝕔𝕖𝕣.” - Sir. Mike Stratton 🧬 Cancer arises from the accumulation of somatic mutations, each carrying clues about the biological and environmental forces that shaped the tumor’s evolution. With the advent of high-throughput sequencing and large-scale projects like TCGA and ICGC, we have uncovered distinct mutational signatures; recurring patterns of DNA alterations that reflect specific mutagenic processes. 🔹 What are mutational signatures? They are characteristic patterns of nucleotide substitutions, insertions, or deletions, shaped by mechanisms such as aging, tobacco exposure, UV light, or defective DNA repair. For example, Signature 1 correlates with age-related deamin...
