Abubakar Abubakar

Recommended book of the weekend: 🍃 ☕ ➡️ "THE BLOOD MERIDIAN" By Comac McCarthy    🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁

“𝓜𝓮𝓽𝓱𝔂𝓵𝓪𝓽𝓲𝓸𝓷 𝓲𝓼 𝓪 𝓵𝓪𝓷𝓰𝓾𝓪𝓰𝓮 𝓬𝓮𝓵𝓵𝓼 𝓾𝓼𝓮 𝓽𝓸 𝓻𝓮𝓶𝓫𝓮𝓻 𝔀𝓱𝓸 𝓽𝓱𝓮𝔂 𝓪𝓻𝓮.” - Prof. Anne Ferguson-Smith 🧬 DNA methylation is a fundamental epigenetic mechanism that regulates gene expression without altering the DNA sequence itself. By adding methyl groups to cytosine residues, particularly within "CpG" regions, cells can selectively activate or silence genes, preserving cellular identity, developmental programming, and genomic stability.            🔹 This process is mediated by DNA methyltransferases (DNMTs), which establish and maintain methylation patterns across cell divisions. In promoter regions, hypermethylation often suppresses transcription, whereas hypomethylation is generally associated with gene activation. These highly coordinated patterns form part of broader epigenetic landscapes; dynamic networks that include histone modifications, chromatin remodeling, and non-coding RNAs...

Recommended book of the weekend: 🍃 ☕ ➡️ "THE WOMAN WITH THE CURE" By Lynn Cullen   🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁

“𝓓𝓝𝓐 𝓭𝓪𝓽𝓪 𝓼𝓽𝓸𝓻𝓪𝓰𝓮 𝓻𝓮𝓶𝓲𝓷𝓭𝓼 𝓾𝓼 𝓽𝓱𝓪𝓽 𝓷𝓪𝓽𝓾𝓻𝓮 𝓼𝓸𝓵𝓿𝓮𝓭 𝓵𝓸𝓷𝓰𝓮𝓿𝓲𝓽𝔂 𝓵𝓸𝓷𝓰 𝓫𝓮𝓯𝓸𝓻𝓮 𝓶𝓸𝓭𝓮𝓻𝓷 𝓮𝓷𝓰𝓲𝓷𝓮𝓮𝓻𝓲𝓷𝓰 𝓫𝓮𝓰𝓪𝓷.” - Esther Lederberg 🧬 In the digital era, the exponential growth of global data is placing unprecedented pressure on conventional storage technologies. As hyperscale data centers expand & energy demands rise, we are increasingly exploring DNA data storage as a next-generation archival solution. By leveraging the molecular architecture of DNA, this technology offers an ultra-compact, durable, and potentially sustainable method for preserving vast quantities of digital information.            🔹 DNA (deoxyribonucleic acid) carries biological instructions through 4 nucleotides: adenine (A), thymine (T), cytosine (C), & guanine (G). These nucleotide sequences can be translated into binary code, allowing digital information to be encoded into synthetic DNA strands. For instance, t...

Recommended book of the weekend: 🍃 ☕ ➡️ "ANATOMY OF A MIRACLE" By Jonathan Miles   🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁

“𝓒𝓮𝓵𝓵 𝓲𝓭𝓮𝓷𝓽𝓲𝓽𝔂 𝓲𝓼 𝓰𝓸𝓿𝓮𝓻𝓷𝓮𝓭 𝓫𝔂 𝓻𝓮𝓰𝓾𝓵𝓪𝓽𝓸𝓻𝔂 𝓷𝓮𝓽𝔀𝓸𝓻𝓴𝓼, 𝓒𝓡𝓘𝓢𝓟𝓡 𝓵𝓮𝓽𝓼 𝓾𝓼 𝓻𝓮𝔀𝓻𝓲𝓽𝓮 𝓽𝓱𝓸𝓼𝓮 𝓷𝓮𝓽𝔀𝓸𝓻𝓴𝓼.” - Emmanuelle Charpentier 🧬 The advent of #CRISPR has transformed genetics, but its most profound impact may lie beyond DNA cutting. By repurposing its systems for programmable gene control, we can modulate expression without altering the underlying sequence; shifting the pattern from editing genomes to regulating them dynamically.          🔹 In engineered systems, catalytically inactive Cas9 (dCas9) retains sequence specificity but lacks cutting ability, enabling precise localization to genomic loci for regulatory purposes.         🔹 Gene regulation is central to cellular identity & homeostasis. Traditional tools (small molecules, transcription factors, & RNA interference) often lack specificity or scalability. CRISPR-based ...