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EPIGENETIC INHERITANCE OF BEHAVIOURAL TRAITS

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“𝔸𝕀 π•žπ• π••π•–π•£π•Ÿ π•˜π•–π•Ÿπ•–π•₯π•šπ•”π•€ π•–π•žπ•–π•£π•˜π•–π••, π•₯𝕙𝕖 π•–π•Ÿπ•₯π•šπ•£π•– π•”π• π•Ÿπ•”π•–π•‘π•₯ 𝕠𝕗 π•’π•”π•’π•¦π•šπ•£π•–π•• π•₯π•£π•’π•šπ•₯ π•šπ•Ÿπ•™π•–π•£π•šπ•₯π•’π•Ÿπ•”π•– 𝕨𝕒𝕀 𝕑𝕦𝕀𝕙𝕖𝕕 π•’π•€π•šπ••π•– π•¦π•Ÿπ•₯π•šπ• π•£π•–π•”π•–π•Ÿπ•₯ π••π•šπ•€π•”π• π•§π•–π•£π•šπ•–π•€ π•šπ•Ÿ π•–π•‘π•šπ•˜π•–π•Ÿπ•–π•₯π•šπ•”π•€ π•“π•£π• π•¦π•˜π•™π•₯ π•šπ•₯ π•“π•’π•”π•œ π•šπ•Ÿπ•₯𝕠 π•€π•”π•šπ•–π•Ÿπ•₯π•šπ•—π•šπ•” π••π•šπ•€π•”π• π•¦π•£π•€π•–.” - Professor Oded Rechavi 🧬 Genetics has long centred on DNA sequence, yet growing evidence shows that heritable information also exists beyond DNA. Epigenetics; chemical modifications such as DNA methylation & histone modification regulates how genes are turned on or off without altering the underlying sequence. Crucially, some of these marks can be shaped by life experiences & transmitted across generations.                    πŸ”Ή Environmental inputs; nutrition, stress, toxins, social context can create stable epigenetic marks that influence gene expressio...

FIRST NIGHT AT THE FOREIGNERS RESTRICTION CENTRE

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After spending a sleepless night outside my apartment on the 29th, I found myself the next night sitting on a hard chair at the KR Puram Police Station. The hours stretched endlessly until the evening of the 30th, when the police inspector assigned two officers to escort me to the Bureau of Immigration; the FRRO office.           At the office, I was instructed to submit all my documents for verification. After a careful review, they confirmed that everything was valid; except my visa, which had unfortunately exhausted. Because of that, I was told I had to be transferred to the FRC.           The journey there was long; about 37 kilometres from the city, and by the time we arrived, it was around 8:20 p.m. My few belongings were checked and taken by the security guards. Later, I was called to the administrative section to collect my papers, hand over my gadgets, and sign some forms.            It ...

A VIOLATION OF POLICE ACTS

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It is with deep sadness that I reflect on the conduct of certain officers of the Bangalore Police. My experience began when I visited the police station to report a case involving a violation of rights. After waiting for hours in the reception area, I was finally called in to meet the inspector on duty.          During our interaction, the inspector asked me to hand over the bag I carried, which contained sensitive personal and professional documents. Without my explicit consent, he took the bag and went through it. This act deeply concerned me, as no police officer has the right to seize or examine a citizen’s or individual personal documents without lawful authority or the individual’s consent.          Under the Indian Police Act, 1861, and the Code of Criminal Procedure (CrPC), 1973, such conduct constitutes a breach of procedure and personal liberty. Specifically:            Section 51 of the CrPC allow...

CLINICAL GENETIC TESTING FOR CANCER SUSCEPTIBILITY πŸŽ—️

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“β„‚π•’π•Ÿπ•”π•–π•£ π•šπ•€ 𝕒 π•˜π•–π•Ÿπ•–π•₯π•šπ•” π••π•šπ•€π•–π•’π•€π•– 𝕒π•₯ π•šπ•₯𝕀 𝕔𝕠𝕣𝕖. π•Œπ•Ÿπ••π•–π•£π•€π•₯π•’π•Ÿπ••π•šπ•Ÿπ•˜ π•šπ•Ÿπ•™π•–π•£π•šπ•₯𝕖𝕕 π•‘π•£π•–π••π•šπ•€π•‘π• π•€π•šπ•₯π•šπ• π•Ÿ π• π•‘π•–π•Ÿπ•€ π•₯𝕙𝕖 𝕕𝕠𝕠𝕣 π•₯𝕠 π•šπ•Ÿπ•₯𝕖𝕣𝕔𝕖𝕑π•₯π•šπ•Ÿπ•˜ π•”π•’π•Ÿπ•”π•–π•£ 𝕓𝕖𝕗𝕠𝕣𝕖 π•šπ•₯ π•“π•–π•˜π•šπ•Ÿπ•€.” - Prof. Bert Vogelstein 🧬 Advances in clinical genetic testing transformed cancer prevention and treatment by revealing inherited mutations that heighten susceptibility to specific cancers. Roughly 5-10% of all cancers are hereditary, often linked to mutations in genes such as BRCA1/2 (breast and ovarian cancers) and MLH1, MSH2, MSH6, and PMS2 in Lynch syndrome (colorectal and endometrial cancers). Identifying these variants enables early detection, preventive measures, and precision therapy prepared to individual genetic profiles.            πŸ”Ή Testing begins with genetic counseling, followed by targeted or multi-gene sequencing using next-generation technologies; now faster ...

WEEKEND READS πŸ“š

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Recommended book of the weekend: πŸƒ ☕ ➡️ "ANNIHILATION" By Jeff Vandermeer   🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁

EPITRANSCRIPTOMICS IN CANCER PROGRESSION πŸŽ—️

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“β„‚π•π• π•Ÿπ•’π• 𝕖𝕧𝕠𝕝𝕦π•₯π•šπ• π•Ÿ π•šπ•€ π•₯𝕙𝕖 π•–π•Ÿπ•˜π•šπ•Ÿπ•– 𝕠𝕗 π•”π•’π•Ÿπ•”π•–π•£ π•‘π•£π• π•˜π•£π•–π•€π•€π•šπ• π•Ÿ; π•₯𝕙𝕖 π•₯π•¦π•žπ• π•£ π•šπ•€ π•Ÿπ• π•₯ π• π•Ÿπ•– π•–π•Ÿπ•₯π•šπ•₯π•ͺ 𝕓𝕦π•₯ 𝕒 𝕑𝕠𝕑𝕦𝕝𝕒π•₯π•šπ• π•Ÿ 𝕠𝕗 π•”π• π•žπ•‘π•–π•₯π•šπ•Ÿπ•˜ π•”π•π• π•Ÿπ•–π•€.” - Professor Peter Nowell (Emeritus) 🧬 Cancer remains a leading cause of morbidity & mortality worldwide, characterized by uncontrolled cell growth, invasion, and metastasis. Beyond genetic alterations, post-transcriptional regulation of RNA has emerged as a critical determinant of cancer biology. Epitranscriptomics, the study of chemical modifications on RNA, provides a dynamic layer of regulation influencing RNA stability, translation, & cellular localization. πŸ”Ή Epitranscriptomic modifications include N6-methyladenosine (m6A), 5-methylcytidine (m5C), pseudouridine (Ξ¨), and RNA editing. These modifications are catalyzed by "writers" (e.g., methyltransferases), recognized by "readers," & reversed by "erasers" (demeth...

WEEKEND READS πŸ“š

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Recommended book of the weekend: πŸƒ ☕ ➡️ "I AM GEORGIA: MY ROOTS, MY PRINCIPLES" By H.E Georgia Meloni    🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁