Abubakar Abubakar

Recommended book of the weekend: 🍃 ☕ ➡️ "THE GOD GENE" By Dean Hamer   🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁

“𝓔𝓿𝓮𝓻𝔂 𝓹𝓸𝓹𝓾𝓵𝓪𝓽𝓲𝓸𝓷 𝓬𝓪𝓻𝓻𝓲𝓮𝓼 𝓪 𝓾𝓷𝓲𝓺𝓾𝓮 𝓬𝓱𝓪𝓹𝓽𝓮𝓻 𝓸𝓯 𝓽𝓱𝓮 𝓱𝓾𝓶𝓪𝓷 𝓼𝓽𝓸𝓻𝔂.” - Brenna Henn 🧬 Population genomics examines genome-wide variation across many individuals to understand ancestry, migration, adaptation, and disease biology. Unlike older methods focused on a few markers, modern genomics analyzes millions of variants simultaneously (linking evolution, medicine, and human history).           🔹 Human diversity reflects both unity and variation. All humans belong to one species and share around 99.9% of DNA, while the remaining variation contributes to traits such as pigmentation, lactose tolerance, immune responses, and other biological differences. These patterns emerged through migration, mutation, natural selection, and environmental interaction over time           🔹 Genomics has transformed our understanding of migration. Evidence strongly supports African origins for modern humans fol...

Recommended book of the weekend: 🍃 ☕ ➡️ "CHROMOSOME 6" By Robin Cook   🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁

“𝓐𝓭𝓿𝓪𝓷𝓬𝓮𝓼 𝓲𝓷 𝓰𝓮𝓷𝓸𝓶𝓲𝓬𝓼 𝓪𝓻𝓮 𝓻𝓮𝓼𝓱𝓪𝓹𝓲𝓷𝓰 𝓱𝓸𝔀 𝔀𝓮 𝓮𝓿𝓪𝓵𝓾𝓪𝓽𝓮 𝓭𝓻𝓾𝓰 𝓼𝓪𝓯𝓮𝓽𝔂 𝓪𝓷𝓭 𝓮𝓯𝓯𝓮𝓬𝓽𝓲𝓿𝓮𝓷𝓮𝓼𝓼.” - Margaret Hamburg 🧬 Variability in drug response has long been observed in clinical practice, where some patients benefit significantly from a medication while others experience minimal effects or adverse reactions. Pharmacogenomics seeks to explain these differences at the genetic level, thereby supporting the broader goal of personalized medicine.           🔹 At the core of pharmacogenomics is the understanding that genetic variations, particularly single nucleotide polymorphisms (SNPs), can affect how drugs are absorbed, distributed, metabolized, and excreted. Enzymes involved in drug metabolism, especially those belonging to the cytochrome P450 family, exhibit genetic variability that can lead to differences in drug efficacy & toxicity.      ...

Recommended book of the weekend: 🍃 ☕ ➡️ "MUTE" By Piers Anthony    🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁🍁

“𝓖𝓮𝓷𝓮 𝓭𝓻𝓲𝓿𝓮𝓼 𝓬𝓸𝓾𝓵𝓭 𝓲𝓻𝓻𝓮𝓿𝓮𝓻𝓼𝓲𝓫𝓵𝔂 𝓪𝓵𝓽𝓮𝓻 𝓽𝓱𝓮 𝓰𝓮𝓷𝓮𝓽𝓲𝓬 𝓶𝓪𝓴𝓮𝓾𝓹 𝓸𝓯 𝔀𝓲𝓵𝓭 𝓹𝓸𝓹𝓾𝓵𝓪𝓽𝓲𝓸𝓷𝓼.” - Dr. Ricarda Steinbrecher 🧬 Gene drives are among the most transformative tools in modern genetic engineering, offering powerful population control with wide-reaching implications. Enabled largely by CRISPR-based systems, they bias inheritance, so engineered traits pass to nearly all offspring rather than the Mendelian 50%, allowing rapid spread through wild populations. This positions gene drives at the forefront of tackling major challenges in public health and environmental management. 🔹 Mechanistically, they copy desired genetic sequences onto homologous chromosomes during reproduction, ensuring preferential inheritance. Often using CRISPR-Cas, we can design traits to suppress or modify populations (for example, mosquitoes engineered for reduced fertility or resistance to malaria). Unlike conventional modifications that fad...