Today's blog is about an experience I had while visiting a religious site on the outskirts of town. As I was leaving, a lady approached me, asking for a donation. Unfortunately, I wasn’t carrying any cash at the time, so I asked her, "Do you use UPI by any chance?" She burst into laughter ๐, smiling at my unexpected question. The lesson here is that we should always be prepared with alternatives, as they might be a way to help others. At the very least, I managed to put a smile on her face, which made the encounter worthwhile ๐
"๐๐ฏ๐ฆ๐ช๐ข ๐ข๐ก๐ฆ๐ฑ๐ฆ๐ซ๐ค, ๐ด๐ฅ๐ฆ๐ ๐ฅ ๐ ๐๐ซ ๐ฐ๐ข๐๐ฏ๐ ๐ฅ-๐๐ซ๐ก-๐ฏ๐ข๐ญ๐ฉ๐๐ ๐ข ๐๐๐ ๐ฐ๐ข๐ฎ๐ฒ๐ข๐ซ๐ ๐ข๐ฐ ๐ด๐ฆ๐ฑ๐ฅ๐ฌ๐ฒ๐ฑ ๐ ๐๐ฒ๐ฐ๐ฆ๐ซ๐ค ๐ก๐ฌ๐ฒ๐๐ฉ๐ข-๐ฐ๐ฑ๐ฏ๐๐ซ๐ก ๐๐ฏ๐ข๐๐จ๐ฐ, ๐ฌ๐ฃ๐ฃ๐ข๐ฏ๐ฐ ๐ ๐ช๐ฌ๐ฏ๐ข ๐ญ๐ฏ๐ข๐ ๐ฆ๐ฐ๐ข ๐๐ซ๐ก ๐ณ๐ข๐ฏ๐ฐ๐๐ฑ๐ฆ๐ฉ๐ข ๐ฑ๐ฌ๐ฌ๐ฉ ๐ฃ๐ฌ๐ฏ ๐ค๐ข๐ซ๐ฌ๐ช๐ข ๐ข๐ก๐ฆ๐ฑ๐ฆ๐ซ๐ค." — Dr. Andrew Anzalone ๐งฌ Base editing and prime editing are revolutionary genome editing technologies that offer precise modifications to DNA sequences. Understanding their mechanisms and exploring their potential applications can lead to significant advancements in various fields. ๐น Base editing involves the direct conversion of one DNA base to another without creating double-stranded breaks. This process relies on the fusion of a DNA-modifying enzyme and a programmable RNA-guided nuclease, such as CRISPR-Cas9. The enzyme catalyzes the chemical conversion of a specific base, resulting in targeted genetic alterations. For example, cytidine deamin...