RNA THERAPEUTICS: BEYOND MRNA VACCINES
"๐ฃ๐ฑ๐ฎ ๐ผ๐พ๐ฌ๐ฌ๐ฎ๐ผ๐ผ ๐ธ๐ฏ ๐ถ๐ก๐๐ ๐ฟ๐ช๐ฌ๐ฌ๐ฒ๐ท๐ฎ๐ผ ๐ฑ๐ช๐ผ ๐ธ๐น๐ฎ๐ท๐ฎ๐ญ ๐ฝ๐ฑ๐ฎ ๐ญ๐ธ๐ธ๐ป ๐ฝ๐ธ ๐ช ๐ท๐ฎ๐ ๐ฎ๐ป๐ช ๐ธ๐ฏ ๐ก๐๐-๐ซ๐ช๐ผ๐ฎ๐ญ ๐ฝ๐ฑ๐ฎ๐ป๐ช๐น๐ฒ๐ฎ๐ผ; ๐ฝ๐ฑ๐ฒ๐ผ ๐ฒ๐ผ ๐ณ๐พ๐ผ๐ฝ ๐ฝ๐ฑ๐ฎ ๐ซ๐ฎ๐ฐ๐ฒ๐ท๐ท๐ฒ๐ท๐ฐ." — Katalin Karikรณ (N.L.)
๐งฌ RNA therapeutics are redefining the future of medicine. While mRNA vaccines gained prominence during the COVID-19 pandemic, they represent just one facet of a rapidly expanding field.
๐น Techniques like antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) can precisely modulate gene expression. This has shown potential in treating disorders such as Duchenne muscular dystrophy, cystic fibrosis, and Huntington’s disease.
๐น RNA-based treatments allow for targeted silencing of oncogenes through RNA interference (RNAi), offering fewer side effects compared to conventional chemotherapy.
๐น RNA vaccines are now being designed to respond rapidly to emerging pathogens and drug-resistant microbes; making vaccine development faster and more adaptable.
๐น mRNAs encoding therapeutic proteins can be delivered to cells to promote tissue repair and regeneration; with potential applications in cardiovascular diseases, diabetes, and neurodegenerative disorders.
⚠️ In an Oystershell, RNA therapeutics extend far beyond mRNA vaccines. From treating genetic and infectious diseases to regenerating tissues, RNA offers a versatile platform with transformative potential. Continued innovation in this space is not just promising; it’s essential for the next leap in human health.
Abubakar Abubakar ✍๐ป
• Sahin, U., Karikรณ, K., & Tรผreci, ร. (2014). mRNA-based therapeutics: Developing a new class of drugs. Nature Reviews Drug Discovery, 13(10), 759–780.
• Pardi, N., Hogan, M. J., & Weissman, D. (2018). mRNA vaccines: A new era in vaccinology. Nature Reviews Drug Discovery, 17(4), 261–279.
• Kotani, A., Kawakami, E., & Shoji, Y. (2022). Therapeutic RNA interference: A new approach to cancer treatment. Nature Reviews Clinical Oncology, 19, 400–415.
• Aartsma-Rus, A., & Corey, D. R. (2017). Antisense therapy for neuromuscular disease. Nature Reviews Neurology, 13(9), 543–554.
#RNATherapeutics #Biotech #GeneticMedicine #RNAi #Innovation #Healthcare
