๐ฝCelebrating freedom, unity, and the spirit that makes U.S.๐บ๐ฒ shine bright. Wishing everyone a safe and joyful Independence Day; a day full of BBQs, freedom and fun.
Today's blog is about an experience I had while visiting a religious site on the outskirts of town. As I was leaving, a lady approached me, asking for a donation. Unfortunately, I wasn’t carrying any cash at the time, so I asked her, "Do you use UPI by any chance?" She burst into laughter ๐, smiling at my unexpected question. The lesson here is that we should always be prepared with alternatives, as they might be a way to help others. At the very least, I managed to put a smile on her face, which made the encounter worthwhile ๐
Recommended book of the weekend: ๐ ☕ ➡️ "GOOGLE IT" By Anna Crowley Redding ๐๐๐๐๐๐๐๐๐๐๐๐๐๐๐๐๐๐๐๐๐๐๐๐
“๐๐ฒ๐ฌ๐ป๐ธ๐ช๐ป๐ป๐ช๐๐ผ ๐ฑ๐ฎ๐ต๐น ๐พ๐ผ ๐ฏ๐ฒ๐ท๐ญ ๐ถ๐ฒ๐ผ๐ผ๐ฒ๐ท๐ฐ ๐ธ๐ป ๐ฎ๐๐ฝ๐ป๐ช ๐ฌ๐ฑ๐ป๐ธ๐ถ๐ธ๐ผ๐ธ๐ถ๐ช๐ต ๐น๐ฒ๐ฎ๐ฌ๐ฎ๐ผ; ๐ฆ๐๐ข ๐ฝ๐ช๐ด๐ฎ๐ผ ๐พ๐ผ ๐ญ๐ฎ๐ฎ๐น๐ฎ๐ป, ๐ฒ๐ท๐ฝ๐ธ ๐ฝ๐ฑ๐ฎ ๐ฌ๐ธ๐ญ๐ฒ๐ท๐ฐ ๐ป๐ฎ๐ฐ๐ฒ๐ธ๐ท๐ผ ๐๐ฑ๐ฎ๐ป๐ฎ ๐ป๐ช๐ป๐ฎ ๐ฟ๐ช๐ป๐ฒ๐ช๐ท๐ฝ๐ผ ๐ฑ๐ฒ๐ญ๐ฎ.” — Ellen Matloff ๐งฌ Chromosomal Microarray (CMA) and Whole Exome Sequencing (WES) are cornerstones of modern genomic diagnostics. Each offers unique insights: CMA identifies large-scale structural changes like copy number variations (CNVs), while WES investigates the exome; the protein-coding portion where most pathogenic mutations reside. ๐น CMA is a first-line tool for neurodevelopmental disorders, intellectual disability, and congenital anomalies. It scans for chromosomal imbalances missed by karyotyping, offering ~15–20% diagnostic yield in such cases. Its speed and cost-effectiveness make it a go-to for initial evaluations. ๐น WES, by contrast, dives into the exonic 1–2% of the genome that harbors ~85% of known disease-causing ...