GENOMICS OF INFLAMMATION & CYTOKINE STORMS

“π”Ύπ•–π•Ÿπ• π•žπ•šπ•” π•§π•’π•£π•šπ•’π•₯π•šπ• π•Ÿ π•šπ•€ π•₯𝕙𝕖 π•€π•”π•£π•šπ•‘π•₯ π•₯𝕙𝕒π•₯ π••π•šπ•”π•₯𝕒π•₯𝕖𝕀 𝕙𝕠𝕨 𝕠𝕦𝕣 π•šπ•žπ•žπ•¦π•Ÿπ•– 𝕀π•ͺ𝕀π•₯π•–π•ž 𝕣𝕖𝕒𝕔π•₯𝕀; π•€π• π•žπ•–π•₯π•šπ•žπ•–π•€ π•¨π•£π•šπ•₯π•šπ•Ÿπ•˜ 𝕒 π•“π•’π•π•’π•Ÿπ•”π•–π•• π•šπ•žπ•žπ•¦π•Ÿπ•– π•£π•–π•€π•‘π• π•Ÿπ•€π•–, π•’π•Ÿπ•• 𝕒π•₯ 𝕠π•₯𝕙𝕖𝕣 π•₯π•šπ•žπ•–π•€ π•€π•”π•£π•šπ•‘π•₯π•šπ•Ÿπ•˜ 𝕒 π••π•šπ•€π•’π•€π•₯𝕣𝕠𝕦𝕀 𝕔π•ͺπ•₯π• π•œπ•šπ•Ÿπ•– 𝕀π•₯π• π•£π•ž.” – Francis S. Collins

🧬 Genomics has reshaped our understanding of inflammation and immune dysregulation. One of the most critical manifestations is the cytokine storm; a runaway immune response marked by excessive cytokine release, driving severe tissue damage in infections and autoimmune disorders.

         πŸ”Ή Genetic predisposition matters. SNPs in cytokine genes (e.g., TNF, IL-6) influence individual susceptibility. Variants in TNF are linked to rheumatoid arthritis and Crohn’s, while IL-6 polymorphisms affect chronic inflammation risk. These insights highlight why immune responses vary so widely across individuals.

          πŸ”Ή Molecular pathways amplify the storm. Dysregulation of NF-ΞΊB signaling and related networks, often shaped by genomic or epigenetic changes, escalates cytokine output. COVID-19 showed this vividly, where hyper-inflammatory cascades involving IL-1, IL-6, and IFN-Ξ³ drove severe outcomes.

          πŸ”Ή Therapeutic implications are profound. Genomic insights underpin biologics like IL-6 blockers (tocilizumab) and TNF inhibitors, transforming patient outcomes. Beyond treatment, genomics enables risk stratification: identifying at-risk individuals before storms occur. Epigenetic modulation adds another frontier; re-orienting inflammatory “switches”.

          ➡️ Decoding the genomics of inflammation is the key to transforming cytokine storms from unpredictable threats into preventable outcomes.

⚠️ ln an Oystershell, the genomics of inflammation is not just academic; it’s a roadmap for precision medicine. By decoding genetic and molecular drivers, we move closer to therapies that prevent, rather than just manage, cytokine storms. In a world facing emerging infections and rising autoimmunity, this knowledge is a healthcare necessity.

Abubakar Abubakar ✍🏻 

• Ahola-Olli, Ari V. et al.
The American Journal of Human Genetics, Volume 100, Issue 1, Page 40 - 50

• Donyavi, T., Bokharaei-Salim, F., Baghi, H. B., et al. (2022). Gene Reports, 27, 101561.

• Hariharan, A., Hakeem, A. R., Radhakrishnan, S., Reddy, M. S., & Rela, M. (2021). Clinical Immunology, 226, 108718.

• Al-Khafaji, Z. M., Al-Naqshbandi, A. A. Y., & Al-Khafaji, A. S. (2022). Human Immunology, 83(9), 671–677.

#Genomics #Inflammation #CytokineStorm #Immunology #PrecisionMedicine #AutoimmuneDiseases #BiologicalTherapies #TNFalpha #IL6 #COVID19 #InflammatoryRespons #MolecularMedicine #Epigenetics #CRISPR #Healthcare #ResearchπŸ”¬⚕️

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