GENOMICS OF INFLAMMATION & CYTOKINE STORMS
“๐พ๐๐๐ ๐๐๐ ๐ง๐๐ฃ๐๐๐ฅ๐๐ ๐ ๐๐ค ๐ฅ๐๐ ๐ค๐๐ฃ๐๐ก๐ฅ ๐ฅ๐๐๐ฅ ๐๐๐๐ฅ๐๐ฅ๐๐ค ๐๐ ๐จ ๐ ๐ฆ๐ฃ ๐๐๐๐ฆ๐๐ ๐ค๐ช๐ค๐ฅ๐๐ ๐ฃ๐๐๐๐ฅ๐ค; ๐ค๐ ๐๐๐ฅ๐๐๐๐ค ๐จ๐ฃ๐๐ฅ๐๐๐ ๐ ๐๐๐๐๐๐๐๐ ๐๐๐๐ฆ๐๐ ๐ฃ๐๐ค๐ก๐ ๐๐ค๐, ๐๐๐ ๐๐ฅ ๐ ๐ฅ๐๐๐ฃ ๐ฅ๐๐๐๐ค ๐ค๐๐ฃ๐๐ก๐ฅ๐๐๐ ๐ ๐๐๐ค๐๐ค๐ฅ๐ฃ๐ ๐ฆ๐ค ๐๐ช๐ฅ๐ ๐๐๐๐ ๐ค๐ฅ๐ ๐ฃ๐.” – Francis S. Collins
๐งฌ Genomics has reshaped our understanding of inflammation and immune dysregulation. One of the most critical manifestations is the cytokine storm; a runaway immune response marked by excessive cytokine release, driving severe tissue damage in infections and autoimmune disorders.
๐น Genetic predisposition matters. SNPs in cytokine genes (e.g., TNF, IL-6) influence individual susceptibility. Variants in TNF are linked to rheumatoid arthritis and Crohn’s, while IL-6 polymorphisms affect chronic inflammation risk. These insights highlight why immune responses vary so widely across individuals.
๐น Molecular pathways amplify the storm. Dysregulation of NF-ฮบB signaling and related networks, often shaped by genomic or epigenetic changes, escalates cytokine output. COVID-19 showed this vividly, where hyper-inflammatory cascades involving IL-1, IL-6, and IFN-ฮณ drove severe outcomes.
๐น Therapeutic implications are profound. Genomic insights underpin biologics like IL-6 blockers (tocilizumab) and TNF inhibitors, transforming patient outcomes. Beyond treatment, genomics enables risk stratification: identifying at-risk individuals before storms occur. Epigenetic modulation adds another frontier; re-orienting inflammatory “switches”.
➡️ Decoding the genomics of inflammation is the key to transforming cytokine storms from unpredictable threats into preventable outcomes.
⚠️ ln an Oystershell, the genomics of inflammation is not just academic; it’s a roadmap for precision medicine. By decoding genetic and molecular drivers, we move closer to therapies that prevent, rather than just manage, cytokine storms. In a world facing emerging infections and rising autoimmunity, this knowledge is a healthcare necessity.
Abubakar Abubakar ✍๐ป
• Ahola-Olli, Ari V. et al.
The American Journal of Human Genetics, Volume 100, Issue 1, Page 40 - 50
• Donyavi, T., Bokharaei-Salim, F., Baghi, H. B., et al. (2022). Gene Reports, 27, 101561.
• Hariharan, A., Hakeem, A. R., Radhakrishnan, S., Reddy, M. S., & Rela, M. (2021). Clinical Immunology, 226, 108718.
• Al-Khafaji, Z. M., Al-Naqshbandi, A. A. Y., & Al-Khafaji, A. S. (2022). Human Immunology, 83(9), 671–677.
#Genomics #Inflammation #CytokineStorm #Immunology #PrecisionMedicine #AutoimmuneDiseases #BiologicalTherapies #TNFalpha #IL6 #COVID19 #InflammatoryRespons #MolecularMedicine #Epigenetics #CRISPR #Healthcare #Research๐ฌ⚕️
